Clinical Use of Diuretics in Heart Failure, Cirrhosis, and Nephrotic Syndrome
نویسندگان
چکیده
Diuretics play significant role in pharmacology and treatment options in medicine. This paper aims to review and evaluate the clinical use of diuretics in conditions that lead to fluid overload in the body such as cardiac failure, cirrhosis, and nephrotic syndrome. To know the principles of treatment it is essential to understand the underlying pathophysiological mechanisms that cause the need of diuresis in the human body. Various classes of diuretics exist, each having a unique mode of action. A systemic approach for management is recommended based on the current guidelines, starting from thiazides and proceeding to loop diuretics. The first condition for discussion in the paper is cardiac failure. Treatment of ascites in liver cirrhosis with spironolactone as the primary agent is highlighted with further therapeutic options. Lastly, management choices for nephrotic syndrome are discussed and recommended beginning from basic sodium restriction to combined diuretic therapies. Major side effects are discussed.
منابع مشابه
2015.09.30_Spiractin DS
Spironolactone acts both as a diuretic and as an antihypertensive agent. It may be given alone or with other diuretic agents that act more proximally in the renal tubule. Increased levels of the mineralocorticoid, aldosterone, are present in primary and secondary hyperaldosteronism, Oedematous states in which secondary aldosteronism is usually involved include congestive cardiac failure, hepati...
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Attemition is drawn to the occurrence of the nephrotic syndrome duriiig chronic heam't failure and to its reversibility over a period of months on a regimen of digitalis, lowsalt diet, and weekly, parenterally administered, mercurial diuretics. It is therefore concluded that the nephrotic syndrome was not caused by mercurial diuretics and is not a eontraindication to their use. Reference is ama...
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ورودعنوان ژورنال:
دوره 2015 شماره
صفحات -
تاریخ انتشار 2015